Evidence

What we know. What we are still measuring.

en-MASCULINE has no published product results yet. It is supported by the ENBIOSIS record: a placebo-controlled trial in men now enrolling, the engine's first formulation in trial, four clinical study papers, and five placebo-controlled trials running now.

  • Six peer-reviewed papers
  • Five registered RCTs
  • Transparent study status
Agar plates with bacterial colonies on a laboratory bench
Current status

Where en-MASCULINE stands

  1. 01

    Formulated with the ENBIOSIS Digital Twin and AI engine.

  2. 02

    Food supplement for men: 90-day programme in three 500 g jars.

  3. 03

    Product study: a placebo-controlled trial of a microbiome-targeted formulation in men is enrolling (NCT07761546). Its link to en-MASCULINE is being confirmed.

  4. 04

    Not suitable for individuals under 18 years of age.

Published evidence

A research record you can open and inspect.

Four clinical study papers, from three studies. All four tested the ENBIOSIS personalised-diet algorithm. None tested en-MASCULINE or any other ENBIOSIS formulation.

  1. 01

    J Clin Med (2022). Single-centre randomised trial in functional constipation, n=50 randomised, 45 analysed, compared with laxative-based standard care. Registry (retrospective, not cited in the paper): NCT05429333.

  2. 02

    Gut Microbes (2022). Open-label pilot in irritable bowel syndrome, n=25. Registry (retrospective, not cited in the paper): NCT04768387.

  3. 03

    Am J Gastroenterol (2024). Multicentre randomised trial, personalised diet vs low-FODMAP in irritable bowel syndrome, n=121 analysed. The two diets gave similar results on the primary endpoint at six weeks (p=0.29). Registry: NCT05646186.

  4. 04

    Gut Microbes (2026). 12-month follow-up of the same trial, open-label with blinded outcome assessment. 25 of 40 participants on the personalised diet were responders (at least a 50-point fall in IBS-SSS), against 10 of 29 on low-FODMAP. The authors describe the finding as hypothesis-generating. Funded by ENBIOSIS Biotechnologies.

Independent recognition

Gold, UK Tech Rocketship Awards 2022, Digital Health category.

ClinicalTrials.gov

Registered trials

Five registered, placebo-controlled randomised trials. Results not yet published.

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